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the hierarchical catalogue of orthologs

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Enabling

  • Transfer of functional knowledge, e.g. from models to human.
  • Learn biology from nature’s experimentation mutating genes.

Scope

  • The broadest coverage of Eukaryotes / Prokaryotes / Viruses.
  • Computed evolutionary traits and collated functional annotations.

Features

  • Comparative charts,
  • mapping of user data,
  • interactive Web GUI,
  • REST API, and SPARQL RDF.
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To guess gene functions "by tradition" we recover gene families by their ancestry, and collate known biological roles of the family members.

The more closely related the species, the more finely-resolved the gene orthologies.

We refer as orthologs to all descendants of a particular single gene of the last common ancestor, thus our operational definition refers to a specific phylogeny radiation for a set of species, termed the level-of-orthology.

Note: notions of orthologs and paralogs are disjoint, e.g. paralogs can be co-orthologs if duplicated after the speciation or can be not if duplicated earlier.

OrthoDB graphical abstract

visual abstract from NAR

Cite us

OrthoDB v10: sampling the diversity of animal, plant, fungal, protist, bacterial and viral genomes for evolutionary and functional annotations of orthologs Kriventseva EK et al, NAR, Nov 2018, doi:10.1093/nar/gky1053. PMID:30395283

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Documentation

Contact

Email: `support[at]orthodb.org Join the OrthoDB-News mailing list (low trafic).